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Precision medicine in ALK-positive NSCLC: Results from the BFAST trial

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Published: 03.10.19
Views: 3505

Prof Solange Peters and Prof Tony Mok

Prof Solange Peters (Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland) and Prof Tony Mok (Chinese University of Hong Kong, Hong Kong) discuss the latest developments presented at ESMO 2019 in ALK-positive non-small-cell lung cancer (NSCLC), including updates in precision medicine.

Prof Mok outlines the current landscape of ALK-positive NSCLC and discusses the BFAST study, which uses a blood-based assay to screen patients to detect patients with ALK fusions.

The experts discuss the clinical utility of this screening tool, which may be beneficial to patients with insufficient tissue for testing and may help oncologists understand the mechanisms of resistance to alectinib in these patients.

Prof Peters concludes by discussing the latest results from the CheckMate 227 trial and the role of ipilimumab plus nivolumab (I-O) combination in ALK-positive patients.

This programme has been supported by an unrestricted educational grant from Roche.

Current landscape of ALK-positive NSCLC
Background of the BFAST study
Screening for ALK-positive NSCLC
Molecular testing methods
Results from the BFAST study
Use of liquid biopsies
Understanding mechanisms of resistance
I-O as a treatment for ALK-positive NSCLC
PDL-1 expression and treatment choice


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