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Role of biomarkers, targeted therapy and tumour mutations in the landscape of bladder cancer

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Published: 30.09.19
Views: 3262
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Prof Petros Grivas and Dr Michiel Van der Heijden

Prof Petros Grivas (University of Washington School of Medicine, Seattle, USA) and Dr Michiel Van der Heijden (Netherlands Cancer Institute, Amsterdam, Netherlands) discuss the role of biomarkers, targeted therapy and tumour mutations in patients with bladder cancer at ESMO 2019

Prof Van der Heijden discusses the clinical use of PDL-1 as a biomarker for these patients, in which an association was detected at baseline. The experts also explore the use of other biomarkers such as tumour mutation burdens and expression patterns in this disease setting.

The experts also discuss the possibility of using a multi-omics approach, whereby different biomarkers could integrated and used as a qualitative method.

Prof Grivas and Dr Van der Heijden conclude by discussing the latest advances in targeted therapy and the main targets for therapy - including FGF receptor mutations.

This programme has been supported by an unrestricted educational grant from Janssen Pharmaceutica (A Johnson & Johnson Company).

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Recent developments in metastatic disease
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Integrating biomarkers using a multi-omics approach
Targeted therapies in urothelial cancer
Optimal biomarkers for FGF-receptor inhibition
Latest drug developments for the third-line setting

 

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