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New methodology developed to monitor patients with glioblastoma

Glioblastoma (GBM) is the most aggressive brain tumour in adults.

Now, it can be treated with neurosurgery, radiotherapy and chemotherapy.

Still, the median life expectancy of patients affected with this pathology is no longer than 15 months.

Within this context, researchers at the Universitat Politècnica de València (UPV) have been working for 15 years in new biomedical tools that can help to the follow-up of this tumour.

The last of them is ONCOHabitats, a platform that allows medical doctors to know the patient's real situation with greater precision according to the vascularity of different areas of the tumour.

"These results consolidate the effort of almost 15 years working in this field. The potential application of this tool has been now validated by seven European hospitals with the first multi-centre clinical study promoted by the Universitat Politècnica de València," said Juan Miguel García-Gómez, coordinator of the Biomedical Data Science Lab-ITACA of UPV.

The seven centres that have taken part in the study are the Hospital Universitario de La Ribera, the Hospital de Manises, the Hospital Clínic in Barcelona, the Hospital Universitario Vall d'Hebrón, the Azienda Ospedaliero-Universitaria in Parma (Italy), the Centre Hospitalier Universitaire in Liège (Belgium) and the Oslo University Hospital (Norway).

The results have been published in the Journal of Magnetic Resonance Imaging.

Key finding for medical prognosis

The methodology developed by the team of UPV researchers helps to discover new areas in the tumour and makes the monitoring of the patient's evolution easier, thanks to new biomarkers.

The key lies in the analysis of five types of Magnetic Resonance Images - four morphological MRIs and one perfusion MRI.

According to the researchers at UPV's Biomedical Data Science Lab-ITACA, from these Magnetic Resonance Images and our methodology, it is possible to establish separated areas inside the tumour and the oedema.

From them, ONCOHabitats allows medical doctors to obtain vascular biomarkers--brain blood volume--in the areas of the active tumour and Infiltrated Peripheral Oedema that are directly linked to the patients' survival, before they undergo surgery.

Until now, most studies have focused on studying the active tumour.

However, we have found a new area of great interest, the Infiltrated Peripheral Oedema.

We have seen that the biomarkers obtained in this area provide very relevant information on the aggressiveness of the tumour and therefore, on the prognosis and follow-up of the patient.

Within the study, researchers worked with 184 patients' MRIs from the seven centres that took part.

The study has proved the robustness of calculating biomarkers using the methodology developed by UPV compared to the variability of applying Magnetic Resonance Images acquisition protocols.

"We have proved in seven hospitals that our methodology is reliable and robust, independently of the variations that can appear when acquiring and processing MRIs and, ultimately, obtaining the biomarkers. These results endorse its viability for the implantation in the clinical practice; the next step is to biologically characterise what it is discovered in the image, and we are already working on it," explained María del Mar Álvarez-Torres, researcher at the Biomedical Data Science Lab-ITACA of the Universitat Politècnica de València.

Source: Universitat Politècnica de València (UPV)



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