Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   

Breast cancer subtypes are different diseases

There is a biological distinction between breast cancers that depend on hormones and those that do not, according to research published in PLoS Genetics.

Scientists previously thought that hormone dependent breast cancers, which usually require treatment with surgery and anti-hormone drugs, originated from the same biological pathway as hormone independent breast cancers, which are treated with surgery and chemotherapy.

The new discovery provides the strongest evidence yet that the subtypes originate from separate pathways and could guide future research into prevention and treatments for the cancer types as different diseases.

Currently, there are fewer treatment options for women with hormone independent breast cancer following surgery.

Cancer Research UK’s Dr Paul Pharoah, lead author based at the University of Cambridge, said: “We looked at five genetic variants associated with breast cancer to see if they were more likely to be found in hormone dependent or independent breast cancers.

“One common genetic variant, FGFR2, was strongly associated with hormone dependent breast cancer, but weakly associated with hormone independent cancer.

“This shows that they have distinct genetic origins, and are different diseases.

“We hope our study will help clarify the biology of breast cancer subtypes and steer future research along two, more distinct paths.”

In the largest study of its kind, the international collaborative effort funded by Cancer Research UK looked at the genetic makeup of over 23,000 breast cancer cases.

Dr Lesley Walker, Cancer Research UK’s director of cancer information, said: “Scientists were previously unsure how different types of breast cancer developed. Although the findings won’t have any immediate effects on the treatment of women with the disease, they are important in helping to define the next steps in our research on the causes of this major cancer.”



Please click on the 'New Comment' link to the left to add a new comment, or alternatively click any 'Add Comment' link next to any existing post to respond. The views expressed here are not those of ecancer. For more information please view our Privacy Policy.

Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation